Management of abnormal pap and biopsies most often involves a colposcopy. A colposcopy uses an instrument, called a colposcope, to look closely at the vagina, vulva, and / or cervix. It is done right in the doctor’s office. Tissue may be collected for biopsy if your doctor sees something suspicious. Abnormal cells are treated by removing them via excision (cutting them out) or ablation (destroying the cells with extreme heat or cold). Excision is most often the course of treatment when cells need to be preserved for biopsy.